Candidates

OT-101 (Trabedersen)

  • Antisense oligonucleotide
  • Inhibits TGF-β2 expression
    • Viral replication for most viruses, including coronaviruses, requires cell cycle arrest
    • Cell cycle arrest is mediated by viral induction of TGF-β
  • Potent in vitro inhibition of viral replication (SARS and COVID-19)
    • EC50 = 2.0 ug/ml; Safety Index >500
  • Safety data in over 200 patients
  • Pre-IND submission completed with

 

Artemisinin

  • Small molecule
  • Inhibits TGF-β activity**
  • Activity is comparable to Remdesivir and Chloroquine
  • Potent in vitro inhibition of viral replication (SARS and COVID-19)
    • EC50 = 0.45 ug/ml; Safety Index = 140
  • Approved product used worldwide for the treatment of malaria